Showing posts with label Pediatrics. Show all posts
Showing posts with label Pediatrics. Show all posts

Monday, September 2, 2013

Obesity in Kids! Assessment

Childhood obesity has made headlines, most recently this month on Malaysian newspaper, 1 and was a dsitinction viva question in IIUM's latest professional exam as well. Malaysia is becoming a fatter nation with fat children. This is all linked to the standard of living and the way we live our lives.


As for kids becoming fat, most are not 100% their own fault. Parental styles contribute, family and cultural lifestyle, as well as peer pressure play roles in this 'disease' of fatness. Some (a lot) take offense to public comments on fatness as well.

Understanding the risks and complications may help in creating awareness in the general public. Only then can an effective counter-measure be implemented.



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Diagnosis and Assessment of Obesity

Diagnosis is based on the BMI centile charts in children and adolescence. This is in contrast to adults where the absolute value of BMI determine whether a person is obese.

Calculation of BMI is the same = Weight (kg) / [ Height (cm) ] square root.

Centile charts here.

Anything above 95% is considered OBESE.



What to do when you see a really fat kid in your clinic?

History Taking:

Family History:
- Fat parents and siblings
- Metabolic syndrome or cardiovascular disease in family

Antenatal and Postnatal History:
- GDM mother
- High birth weight
- Non-exclusive breastfeed
- Early introduction to sweetened fluids and food

Monster 5 kg.


Social History:
- Diet history: frequency of snacks, carbonated or sweet drinks, eating as a family, eating outside.
- Physical activity: frequency, types of activities, 'screen' time ie. TV, internet, playstation.
- Attitude towards obesity, and losing weight. 
- School and peer: Bullying, bully, taunting.

Symptoms (related to Complications or Comorbids, see later)


Physical Examination

Short statured (Cushing syndrome)
Acne (PCOS, Cushing syndrome) 
Acanthosis nigricans (Metabolic syndrome, PCOS)

Blood pressure

Abducent nerve palsy, papilloedema (Pseudoumor cerebri)

Striae (Cushing syndrome)
Abdominal pain (Gallstone)
Hepatomegaly (Non-alcoholic fatty liver disease)

Limited range of movement of hips (Slipped capital femoral epiphysis)
Bowing of legs (Blounts disease)


Investigations

Fasting lipid profile
Fasting sugar profile
Liver function test

Imaging as indicated according to complications.
Hip and lower limb x-ray
Abdominal ultrasound


Complications and Comorbids
 
 Respiratory System
  • Asthma
  • Obstructive sleep apnea
 Cardiovascular System
  • Hypertension
Endocrine System
  • Metabolic syndrome
  • Diabetes mellitus
GIT System
  • GERD
  • Non-alcoholic fatty liver disease
  • Gallstone
Musculoskeletal System
  • Blount disease
  • Slipped capital femoral epiphysis
Neurological
  • Pseudotumor cerebri
Psychological
  • Depression
  • Worsening school performance
  • Eating disorders

TO BE CONTINUED... Management and Prevention

References:
1. http://www2.aap.org/obesity/pdf/COANImplementationGuide62607FINAL.pdf
2. CPG, Obesity, Ministry of Health Malaysia
3. Kliegman, Robert M., et al., Nelson Textbook of Pediatrics, 18th ed., Elsevier Saunders.

Yang tengah tu pon gumok juga


Tuesday, July 9, 2013

Neonatal Stridor: Short Notes


Neonatal Stridor

Stridor is a harsh, raspy breath sounds heard during breathing that may indicate an upper airway obstruction. It may occur during inspiration, expiration or may be biphasic depending on the location of the obstruction.

Anatomic and Physiologic Considerations

-       Smaller caliber of airway
-       Higher position and longer epiglottis
-       Lower total lung capacity
-       Increased functional residual capacity dependant on:
o   Increased respiratory rate
o   Active glottic narrowing during expiration
o   Use of expiratory muslces for respiration



Assessment

Babies with stridor should be assessed further for any evidence of respiratory distress:

-       Cyanosis
-       Chest retraction
-       Tachypnea
-       Grunting
-       Nasal flaring

Some may present with difficulty in feeding, recurrent choking or cough.

Investigations:

-       Flexible direct laryngoscopy
-       Rigid direct laryngoscopy

Differential Diagnosis

Supraglottic

-       Laryngomalacia (Commonest cause)


Omega shaped epiglottis






Glottic

-       Vocal cord paralysis (Second commonest cause)
-       Laryngeal web

Subglottic

-       Subglottic stenosis
-       Subglottic hemangioma
-       Tracheomalacia
-       Trachea stenosis with complete tracheal ring
-       Pulmonary vascular ring









 Some websites for demonstrations and information:




Wednesday, May 15, 2013

URTI: Latest Recommendations - Nothing!

The Common Cold

The scourge of every kid and parents! Which moms wouldn't bring their kid to the nearest clinic asking for antibiotics and vitamin C?

However, evidence based reviews suggest 'wait and see' for most of these problems.

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Most URTIs are self limiting.

Persistent symptoms more than 14 days should raise suspicions of other possible diagnosis.

Latest reviews suggest supportive measures in treatment of the common cold.
  • Adequate hydration
  • Warm fluids (ie. hot soup, tea)
  • Honey
  • Saline nasal spray or irrigation
  • COLD humidifier (not warm)
The above measures have no strong evidence but is safe and inexpensive for use.

Does not recommend:
  • Over-the-counter cough and cold medications in children < 6 yo
  • Using antibiotics in ABSENCE of secondary bacterial infections
  • Antihistamines, ipratropium, decongestants in nasal congestion. Side-effects may bring more harm that benefits
  • Antitussives, mucolytics or expectorants in treatment of coughs as there is no proven benefits and may cause adverse effects. WHO however recommend us of dextrometrophan in cases of severe symptoms but diagnosis needs to be reviewed and revised.
  • Bronchodilators in non-asthmatic patients.
  • Topical rubs containing aromatics for nasal obstruction
  • Zinc and vitamin C
Symptomatic treatment initiated only even it is bothering the child or family members (ie. difficulty sleeping)
  • Fever - in children > 3 mo, treated with acetaminophen or ibuprofen
  • Nasal Congestion - as mentioned above.
  • Cough - Ingestion of warm fluids or honey.
Prevention

  • Education on hand hygiene and non-contact of affected individual.
  • No immunization to prevent common cold.
  • Zinc, vitamin C are not proven to prevent the common cold.
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There you have it, URTI treatment in a nutshell.

In our community I doubt parents would buy that. Perhaps placebo should do the trick?

Reference:

Pappas, D. E., et al., The Common Cold in Children, Treatment and Prevention, UpToDate Article, 2013.


Some Doses of Commonly used drugs:

Paracetamol - 15 mg/kg (max 4 g/day) oral
Dextromethorphan - 0.2 - 0.4 mg/kg 6 - 8 hourly oral
Bromhexine - 0.3 mg/kg tds oral 7 days
Actifed (Triprolidine HCl 1.25 mg, pseudoephedrine Hcl 30 mg) - > 12yo 10mL, 6 - 12 yo 5 mL, < 6yo 2.5 mL tds oral (syrup).
Benadryl (diphenhydramine Hcl 12.5mg, ammon Cl 125 mg) - > 1 yo 1/2 - 1 tsp 4 hourly (Max 6 tsp/24 hours)
Clarinase (Loratidine 5 mg, pseudoephedrine 60 mg) - > 30 kg 5 mL, < 30 kg 2.5 mL bd syrup.

Tuesday, April 30, 2013

Anencephaly: Short Notes



Definition:
Absence of the calvaria above the bony orbits. May be associated with absence of cerebral hemisphere.

Incidence:
1/1000 live births.

Pathogenesis:
Failure of closure of cephalad neural tube at 25 - 27 days post conception.

Risk of Recurrence:
2 - 4 % with 1 affected siblings. 10% with 2 affected siblings.

Diagnosis (Antenatal):
  • Absent bony calvaria
  • Orbits well visualized
  • Absence of supratentorial brain
  • Residual brain
  • Associated polyhydromnios, due to decreased fetal swallowing
  • Associated spina bifida
Associated Anomalies:
  • Spina bifida
  • Urinary tract anomalies
  • Cleft lip / palate
  • GIT anomalies (ie. omphalocoele, intestinal aganglionosis)
  • Cardiac anomalies

Prognosis:
Incompatible with life. Some may live up to a week postnatally.

Prevention:
Folic acid supplements, recommended 4 mg per day a month preconception and 3 months after.
With-holding anticonvulsants (folic acid antagonist, ie. valproate, carbamezapine, phenytoin, trimetoprim)


References
1. Nyberg, David A., et al., Diagnostic Imaging of Fetal Anomalies, Lippincott Williams & Wilkins, 2003.

2. Tomita T., et al., Anencephaly, UpToDate Article, 2012.

Future Topics:
- Folic acid in prevention of neural tube defects.
- Feasibility of organ donation of anencephalic babies
- Spina bifida and other neural tube defects.


 

Friday, February 15, 2013

Tetralogy of Fallot: The Basics

Pathophysiology:

Tetralogy of Fallot occurs when there is a deviation of the development of the muscular septum of the ventricles antero-cephaladly. This would result in 3 of the 4 features of the 'tetralogy':
  1. Ventricular septal defect (VSD)
  2. Pulmonary stenosis 
  3. Over-riding of the aorta
  4. Right ventricular hypertrophy (Secondary to compensation of the ventricles from pulmonary outflow obstruction)
All these defects occur to variable degrees influencing the manifestation and severity of the condition in affected children.

These defects result in mixing of oxygenated and deoxygenated blood between the VSD from a left-to-right shunt outflow of mixed blood into the aorta causing cyanosis. Cyanosis is worsened when the pulmonary outflow tract is severely restricted and made worse during exacerbation hypercyanotic spell also known as Tet spell.

Compensation may occur via a patent ductus arteriosus (PDA) in newborns and major aortopulmonary collateral arteries (MAPCA).

Clinical Features:
  • Cyanosis. In mild to moderate cases cyanosis may be absent depending on the severity of the pulmonary outflow obstruction.
  • Hypercyanotic spells or Tet spell. 
    • Worsening early in the morning when crying or on exertion or vigorous activities. 
    • May be severe to result in unconsciousness. 
    • Hypoxia may occur to varying degrees which may progress the metabolic acidosis.  
  • Failure to thrive
  • Delayed puberty
  • Clubbing 
  • Parasternal heave
  • Systolic thrill and ejection systolic murmur usually heard over the upper parasternal area due to pulmonay obstruction.
  • Murmur maybe almost absent in hypercyanotic spells due to complete obstruction of the pulmonary outflow tract.
Diagnosis:
  •  Echocardiography: Standard modality for diagnosis. Able to outline extent of defects.
  • Chest X-ray: 
    • Coeur en sabot: Boot shaped heart
    • Right-sided aortic arch
    • Diminished pulmonary vasculature (not prominent)
Boot-shaped heart with right ventricular enlargment.
 
  • ECG:
    • Right axis deviation
    • Prominent R wave on right precordial chest leads and S wave in lateral precordial chest leads.
    • Bifid P wave
Complications:
  • Polycythemia
  • Cerebral thromboses in severe cases of polycythemia
  • Infective endocarditis
  • Brain abscess
ALMOST NEVER HEART FAILURE!

References:

1. Kliegman, Robert M., et al., Nelson Textbook of Pediatrics, 18th ed., Elsevier Saunders.

2. Doyle, T., et al., Pathophysiology, Clinical Features and Diagnosis of Tetralogy of Fallot, UpToDate article, (2013).

3. Bailliard, F., et al, Tetralogy of Fallot.

Future Topics:

- Management of TOF
- Surgical Management of TOF
- Cyanotic heart disease
- Transposition of Great Arteries.

Friday, December 28, 2012

Hydrops Fetalis: Workup

Historically, hydrops were first associated with fetal anemia caused by destruction of fetal red blood cells by antibodies produced by Rh negative mothers in response to antigenic exposure of a Rh positive fetus, usually from the first pregnancy. What result is a severely edematous fetus which characterizes this condition. In today's era where blood group is screened and Rh alloimmunization is prevented with anti Rh(D) immunoglobulin, the majority of causes of hydrops are non-immune related (~90%).

There is a whole list to the causes of hydrops. Typing every single condition would not be beneficial. I feel that work-up to the cause of hydrops should be aimed to detect maternal conditions that may lead to hydrops as well as anomalies that may recur. This is to prevent recurrence, if possible, in future pregnancies as mortality of neonates with hydrops is at 50% depending on the cause of hydrops. 

DIAGNOSIS

Diagnosis are usually made antenatally with detection of the following:
  • Skin edema
  • Scalp edema
  • Ascites
  • Pleural effusion
  • Pericardial effusion (most difficult to see)
CAUSES

I will not list all the possibilities but most of the common and important ones:

Immune-mediated:
Rhesus alloimmunization

Nonimmune causes:

Congenital anomalies
- Cystic hygroma
- Turner's (XO monosomy)
- Trisomies (21 most common)

Hematological
- Alpha thalassaemia
- Massive fetomaternal hemorrhage

Cardiac anomalies (all sorts)

Thoracic anomalies
- Congenital cystadenomatoid malformation (CCAM)
- Any mass/lesions that may cause increase thoracic pressure

Infections
- TORCHES (Toxoplasmosis, rubella, cytomegalovirus, Herpes simplex, syphilis [most common])
- Parvovirus B19

Metabolic Disorders
ie. Gaucher's disease, Tay-Sach's disease, sialidosis, generalized (GM1) gangliosidosis

Twinning
- Twin-twin transfusion syndrome

Others
- Skeletal dysplasias


WORK-UP

Antenatal

As usual, history from the mother should be obtained when hydrops is first detected. Family history of genetic anomalies, consanguineous marriage should be obtained. Recurrence are more likely in families with such histories ie. Alpha thalassaemia, metabolic disorders (which most are autosomal recessive), congenital anomalies.

History of exposure to infections may also be beneficial.

Rhesus negative mothers should always be ruled out.

Other associated anomalies may be looked for and detected during the initial ultrasound or repeated in more expert hands later. Amniocentesis for fetal karyotyping may be obtained after counselling. If infection is suspected, amniotic fluid may be sent for cultures or PCR if facilities are available. 

Postnatal

Evaluation of the neonate post-delivery should always be after initial resuscitation as these fetus tends to have turbulent births.

Relevant physical examination:
  • Cyanosis - may indicate underlying structural heart anomaly
  • Hepatosplenomegaly - metabolic disease, congenital infections
  • Features of Turner's, Down's and other features of chromosomal anomalies
  • Congenital anomalies - cystic hygroma, dysplasia
  • Hypotonia - metabolic disorders, dystrophies
  • Placenta - in case of TTTS
Investigations:
  • FBC - To rule out anemia or determine severity of anemia
  • PBF - To look for hemolysis
  • Kleihauer-Betke test - if fetomaternal hemorrhage suspected
  • ECG - to rule out arrythmias
  • Echocardiography - to rule out cardiac anomalies
  • Chest x-ray (Pleural effusion, CCAM)
  • Infection screen (TORCHES)
  • Karyotyping (if not yet done antenatally and if suspicious of chromosomal anomalies)
  • Metabolic screen (for metabolic diseases)
Management are then commenced according to cause and prognosis.

Postmortem:

If the fetus delivers as a stillbirth or had an early neonatal death, postmortem may be important to determine underlying anomalies or condition.


Determining the cause of hydrops is important to rule out causes that are potentially preventable or predictable, especially those associated with chromosomal anomalies. Future pregnancies may be followed-up more carefully with anticipation of treatment better. Mothers should always be counselled for possibilities for recurrence and next pregnancy planned well.

As mentioned this article only covers some of the causes and work-up for the hydrops patient. Mode of delivery, management of the fetus is not discussed in details here but both depends on the cause of hydrops and after further discussions with the parents.


References:
Creasy, Robert K., et al., Maternal Fetal Medicine, Principles and Practice, 6th Ed.
Speer, Micheal E., Postnatal Care of Hydrops Fetalis, Up-to-Date Article, 2012.

Sunday, December 23, 2012

Neonatal Resuscitation: The Basics

Fortunately most term babies are born without complications or needing help for resuscitation. About 10% do and that's a significant number. Basic knowledge of neonatal resuscitation must be available to all medical staffs (doctors and nurses) working in the labour room or the emergency department for that matter as mothers in advanced labour may just pop-up in the emergency department in the middle of the night.

The algorithm above pretty much sums up the steps of neonatal resuscitation covering even babies whom are delivered 'normal' without complications. There are many other variations but this is the one that I'm most used to.

Most times, the outcome of delivery can be roughly predicted even before birth itself. Knowledge of the patient's history helps a lot in anticipating outcome of delivery.

The initial step as in the box above emphasize the recognition of a baby in need of resuscitation. Four basic questions must be answered:
  • Is the baby term?
  • Is the liqour clear?
  • Is the baby crying or breathing?
  • Is the muscle tone good?
If any of the above is NO, then the next step of resuscitation is required. 

Even the first two questions above can be answered before delivery and can be anticipated. With anticipation comes preparation and with good preparation hopefully better outcome may be borne out of the delivery.

If all those answered above are YES, then the baby maybe passed on to the mother unless otherwise contraindicated, for skin to skin contact and initiation of breast feeding and routine care.

Another interesting note is that delayed cord-clamping should be practiced (as late as 1 minute after delivery) as there is evidence of reduced incidence of transfusion and increased iron storage in babies with delayed cord-clamping.

INITIAL STEPS TO RESUSCITATION

Below are the basic initial steps for resuscitation. All these steps are to be done ideally within 30 minutes and the baby reevaluated afterwards to assess success of resuscitation and need to proceed with the next step.

Provide warmth and Dry
- Baby is to be placed under radiant warmers.
- If baby is preterm, best to be wrapped in plastic wrappings as preterms are more likely to lose heat more easily

Position and maintain airway
- Positioned in sniffing position.

Stimulate
- Only back stimulation is necessary up to 2 to 3 times.
- Slapping the feet of babies should not be in practice today.

*Clear airway
- Latest guidelines from WHO states that babies whom are breathing on their own should not have regular suctioning, even if meconium was present.
- Suctioning should only be done if there are evidence of excessive secretions.
- There is no evidence in improved outcomes in babies suctioned intrapartum (after delivery of head, before delivery of shoulder) when meconium is present.
- If meconium is present and baby is not *vigorous, direct-suctioning with the meconium aspirator should be initiated straight away, even before positive pressure ventilation is performed.
- Direct suctioning is done until airway produces clear returns or baby becomes bradycardic.

*vigorous = not breathing, limp, heat rate <60 bpm.


POSITIVE PRESSURE VENTILATION (PPV)

- If the baby is still apneic or heart rate is less than 60 bpm after the initial steps, positive pressure ventilation should be initiated.
- 40 to 60 cycles of breath should be given per minute.
- Ensure there is chest rise. If not, reposition in sniffing position.
- Intubation is to be considered if unable to ventilate.
- Excessive pressure or 'bagging' must be avoided for risk of pneumothorax.
- Heart rate is to be evaluated after 60 seconds of PPV with target > 100 bpm.
- SpO2 monitoring may be attached during the resuscitation, best SpO2 probe to be placed at pre-ductal areas ie. right hand. One must be aware that oxygen saturation is not maximal in the newborn till at least 10 minutes after delivery.

Preductal SpO2 According to Duration after Birth
  • 1 minute - 60-65%
  • 2 minutes - 65-70%
  • 3 minutes - 70-75%
  • 4 minutes - 75-80%
  • 5 minutes - 80-85%
  • 10 minutes - 85-95%

CHEST COMPRESSIONS

- PPV and adequate ventilation should be done before initiation of chest compressions.
- Chest compressions done if heart rate < 60 bpm.
- Best to be done with 2 thumbs on the sternum with the other fingers around the baby for better control of pressure.
- Depth of compression should be 1/3rd of the AP diameter of the baby.
- Ratio of breath to compressions should be 1:3.
- 2 finger technique done if space is needed for procedures ie. insertion of umbilical catheters.
- Intubation must be considered at this stage if not earlier.

MEDICATIONS

- Rarely are medications need in neonatal resuscitation (as compared to adult resuscitation),
- If compressions are ineffective, IV adrenaline 0.01 - 0.03 mg/kg is to be given via intraumbilical venous catheter. If not, adrenaline 0.05 - 0.1 mg/kg may be administered through an endotracheal tube.
- Adrenaline should be diluted in 1:10000 (0.1 mg/mL)
- Adrenaline may be repeated every 3 to 5 minutes if heart rate remains < 60 bpm.
- IV bolus of N/S or HM 10 mL/kg may be given in suspected hypovolemia or anemic babies.
- Naloxone should not be given routinely.


Other Points
- Remember that resuscitation of the neonate should NOT be done alone.
- Always call for help of someone more experienced.
- Know what is available ie. laryngeal mask airway may be beneficial
- Know when to quit (Perhaps I'll write about this in other articles)
- And always inform the mother or parents of what was done and why and the outcome.
- Remember documentation.



That's it for now. This is just a 'short-note' of mine that I hope will be beneficial for me and to whoever that reads this. It's definitely incomplete but I hope will cover more of the basic stuff. Future related articles that I'll be posting may be on intubations, UVC insertions, other methods of ventilations, and withdrawing treatment, all important aspects of neonatal resuscitation. Let's hope that I've obtained at least a certificate for NRP by then :D


References:
- Neonatal resuscitation Textbook 5th Edition.
- Special Report - Neonatal Resuscitation, 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care, PEDIATRICS, Journal of American Academy of Pediatrics
- WHO Guidelines on Basic Newborn Resuscitation 2012.